Majority of the reported complications associated with erythropoietin therapy are not due to the recombinant product but due to the resultant increase in hematocrit and blood viscosity.
Tag: Epoetin alfa
How To Treat Anemia By Erythropoietin Therapy?
There are two important reasons to correct anemia in renal failure patients. One is to improve or reverse the symptoms associated with renal anemia, and the second is to seize or reverse the deleterious effect of long-standing anemia on the heart and other organs which lead to improved cardiovascular morbidity and mortality in dialysis patients.
Action Of Erythropoietin In Dialysis Patients
Erythropoietin therapy is one of the greatest inventions in Nephrology and it changed the way we treat anemic patients, which we were only dependent on blood transfusions in the past. Erythropoietin therapy is the easiest way to treat anemia in CKD
Erythropoietin Therapy
Erythropoietin therapy is one of the greatest inventions in Nephrology and it changed the way we treat anemic patients, which we were only dependent on blood transfusions in the past. Erythropoietin is a 165 amino acid secreted glycoprotein. Recombinant erythropoietin is available in two forms α-epoetin and β-epoetin and Darbepoetin is a longer acting erythropoietin with the half-life approximately three folds longer than recombinant erythropoietin. 1µg darbepoetin is equal to 200 IU OF erythropoietin.This has been achieved by adding two extra N – linked carbohydrate side – chains to the erythropoietin molecule. As a result, darbepoetin requires less frequent dosage, usually once a week or once in every two weeks and sometimes only once a month in stable hemodialysis patients.
Management of Anemia in Chronic Kidney Disease (CKD)
There are two important reasons to correct anemia in renal failure patients. One is to improve or reverse the symptoms associated with renal anemia, and the second is to seize or reverse the deleterious effect of long-standing anemia on the heart and other organs which lead to improved cardiovascular morbidity and mortality in dialysis patients.
Development Of Anemia In Dialysis Patients
Anemia is one of the major Hematological complications in Chronic Kidney Disease (CKD). As renal function declines, there is a progressive worsening of anemia, which becomes clear once serum creatinine rises above 300 µmol/L or GFR falls below 30 ml/min/1.73m² and its major cause is the loss of cells in the kidney responsible for the synthesis and secretion of erythropoietin.
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